MLB wild-card round odds: The favorites for every series

The 2025 MLB playoffs are here, kicking off with the wild-card round — four best-of-three showdowns — all taking place at the site of the higher seeds.

The two division winners in each league with the best records (Milwaukee Brewers, Philadelphia Phillies, Toronto Blue Jays, Seattle Mariners) all get a chance to rest their regulars and set up their rotations for the next round, where they’ll square off with the winners of the series outlined below beginning Saturday, Oct. 4.

Odds to win series: Cubs (-120), Padres (Even) Exact series result: Cubs to sweep (+240), Cubs in 3 (+260), Padres to sweep (+300), Padres in 3 (+275)

For more on the MLB playoffs, check out each team’s odds to win the World Series.

All odds accurate as of publish time. For more, go to ESPN BET Sportsbook.

Cincinnati Reds at Los Angeles Dodgers All games at Dodger Stadium, Los Angeles

Odds to win series: Dodgers (-250), Reds (+200) Exact series result: Dodgers to sweep (+145), Dodgers in 3 (+225), Reds to sweep (+500), Reds in 3 (+400)

San Diego Padres at Chicago Cubs All games at Wrigley Field, Chicago

Detroit Tigers at Cleveland Guardians All games at Progressive Field, Cleveland

Odds to win series: Guardians (-110), Tigers (-110) Exact series result: Guardians to sweep (+325), Guardians in 3 (+225), Tigers to sweep (+225), Tigers in 3 (+350)

Boston Red Sox at New York Yankees All games at Yankee Stadium, New York

Odds to win series: Yankees (-185), Red Sox (+150) Exact series result: Yankees to sweep (+185), Yankees in 3 (+225), Red Sox to sweep (+450), Red Sox in 3 (+325)

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